反应详情

To a solution of 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid hydrazide trifluoroacetic acid salt (Preparation 10—route 1, 0.110 g, 0.34 mmol) in DMF (3 mL) was added DIPEA (170.0 μL, 1.02 mmol). To the stirred solution, HOBt (0.046 g, 0.34 mmol), EDCI (0.078 g, 0.41 mmol), DIPEA (120.0 μL, 0.68 mmol) and thiophene-3-carboxylic acid (0.044 g, 0.34 mmol) were added. The reaction mixture was stirred at rt for 16 h and then concentrated in vacuo to give an oil. On addition of ethyl acetate to the oil, a solid precipitated. The solid was filtered and dried to give the title compound. m/z (ES+)=321 [M+H]+; RT=2.84 min.

1. concentrationconcentrated in vacuo
2. customto give an oil
3. customa solid precipitated
4. filtrationThe solid was filtered
5. customdried