Nitrogen → 17-[2-(3-Fluoro-phenyl)-7-methoxy-8-methyl-quinazolin-4-yloxy]-13-methyl-2,14-dioxo-3,13,15-triaza-tricyclo[13.3.0.0*4,6*]octadec-7-ene-4-carboxylic acid ethyl ester

HRID 1443509Notes

Reaction equation

HRID 1443509 reaction equation
C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.[CH2:20]([O:22][C:23]([C:25]12[CH2:42][CH:41]1[CH:40]=[CH:39][CH2:38][CH2:37][CH2:36][CH2:35][N:34]([CH3:43])[C:33](=[O:44])[N:32]1[CH:28]([CH2:29][CH:30]([OH:45])[CH2:31]1)[C:27](=[O:46])[NH:26]2)=[O:24])[CH3:21].[F:47][C:48]1[CH:49]=[C:50]([C:54]2[N:63]=[C:62](O)[C:61]3[C:56](=[C:57]([CH3:67])[C:58]([O:65][CH3:66])=[CH:59][CH:60]=3)[N:55]=2)[CH:51]=[CH:52][CH:53]=1.N#N.CC(OC(/N=N/C(OC(C)C)=O)=O)C>C1COCC1.CN(C=O)C>[CH2:20]([O:22][C:23]([C:25]12[CH2:42][CH:41]1[CH:40]=[CH:39][CH2:38][CH2:37][CH2:36][CH2:35][N:34]([CH3:43])[C:33](=[O:44])[N:32]1[CH:28]([CH2:29][CH:30]([O:45][C:62]3[C:61]4[C:56](=[C:57]([CH3:67])[C:58]([O:65][CH3:66])=[CH:59][CH:60]=4)[N:55]=[C:54]([C:50]4[CH:51]=[CH:52][CH:53]=[C:48]([F:47])[CH:49]=4)[N:63]=3)[CH2:31]1)[C:27](=[O:46])[NH:26]2)=[O:24])[CH3:21]

Participants

8

Reactant 5

HCID 947NitrogenHCID 11776TriphenylphosphineHCID 5363146Diisopropyl azodicarboxylateHCID 6841037217-Hydroxy-13-methyl-2,14-dioxo-3,13,15-triaza-tricyclo[13.3.0.0*4,6*]octadec-7-ene-4-carboxylic acid ethyl esterHCID 1784877302-(3-fluorophenyl)-7-methoxy-8-methyl-1H-quinazolin-4-one

Product 1

HCID 6868730917-[2-(3-Fluoro-phenyl)-7-methoxy-8-methyl-quinazolin-4-yloxy]-13-methyl-2,14-dioxo-3,13,15-triaza-tricyclo[13.3.0.0*4,6*]octadec-7-ene-4-carboxylic acid ethyl esterYield 75%

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 8028TetrahydrofuranSolvent

Procedure

PPh3 (415 mg, 1.58 mmol) was added to a stirred solution of the alcohol 51 (300 mg, 0.79 mmol) and the quinazolinol 127 (247 mg, 0.87 mmol) in dry THF (35 mL) and dry DMF 7 mL. The reaction was placed under an inert atmosphere (N2) at room temperature. DIAD (311 μL, 1.58 mmol) was added. The reaction mixture was stirred for 18 h. A precipitation was formed in the flask and more white solid precipitated after addition of 40 mL diethyl ether. The precipitation was filtered off and washed with diethyl ether and dried under vacuum which gave the pure title compound (381 mg, 75%). LRMS (M+H) 646.

Workup

  1. customA precipitation
  2. customwas formed in the flask and more white solid
  3. customprecipitated
  4. additionafter addition of 40 mL diethyl ether
  5. customThe precipitation
  6. filtrationwas filtered off
  7. washwashed with diethyl ether
  8. customdried under vacuum which

Sources & evidence

ORD record
ord-051228f4746c4f98947d57ae389962f3
Source dataset
uspto-grants-2010_02
Patent number
US07659245B2

Reaction notes

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