HRID1464588

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID750

Glycine

C2H5NO2

HCID5960

L-Aspartic acid

C4H7NO4

HCID6057

L-Tyrosine

C9H11NO3

HCID6137

L-Methionine

C5H11NO2S

HCID6140

L-Phenylalanine

C9H11NO2

HCID7519

Anisole

C7H8O

HCID7520

Benzene, (methylthio)-

C7H8S

HCID10902

Ethane-1,2-dithiol

C2H6S2

结构：CSCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O

HCID9833444

Sincalide

C49H62N10O16S3

PRODUCTS

生成物

结构：CSCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O

HCID444998

未命名化合物

PROCEDURE

实验过程

The cleavage yield of CCK-8 peptide, using a similar procedure with scavengers (thioanisole, anisole and 1,2-ethanedithiol) present in the cleavage cocktail, was about 95%. AAA showed a composition of: Asp 2.03, Gly 1.04, Met 1.92, Tyr 0.99, Phe 1.02, which is characteristic of CCK-8.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-78eed412d5a6423db2dc1185692fcbc0
来源数据集: uspto-grants-1994_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05306562
来源说明: uspto-grants-1994_04

反应 SMILES

[C:1]1(SC)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:9]1([O:15]C)[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.[CH2:17]([SH:20])[CH2:18]S.N[C@H:22](C(O)=O)CC(=O)O.NCC(O)=O.N[C@H](C(O)=O)CCSC.N[C@H](C(O)=O)CC1C=CC(O)=CC=1.N[C@H](C(O)=O)CC1C=CC=CC=1.[CH3:69][S:70][CH2:71][CH2:72][C@H:73]([NH:122][C:123]([C@@H:125]([NH:138][C:139]([C@@H:141]([NH2:146])[CH2:142][C:143]([OH:145])=[O:144])=[O:140])[CH2:126]C1C=CC(OS(O)(=O)=O)=CC=1)=[O:124])[C:74]([NH:76][CH2:77][C:78]([NH:80][C@H:81]([C:92]([NH:94][C@H:95]([C:100]([NH:102][C@H:103]([C:108]([NH:110][C@H:111]([C:119]([NH2:121])=[O:120])[CH2:112]C1C=CC=CC=1)=[O:109])[CH2:104][C:105]([OH:107])=[O:106])=[O:101])CCSC)=[O:93])[CH2:82][C:83]1[C:91]2[C:86](=[CH:87][CH:88]=[CH:89][CH:90]=2)[NH:85][CH:84]=1)=[O:79])=[O:75]>>[NH2:146][C@H:141]([C:139]([NH:138][C@H:125]([C:123]([NH:122][C@H:73]([C:74]([NH:76][CH2:77][C:78]([NH:80][C@H:81]([C:92]([NH:94][C@H:95]([C:100]([NH:102][C@H:103]([C:108]([NH:110][C@H:111]([C:119]([NH2:121])=[O:120])[CH2:112][C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)=[O:109])[CH2:104][C:105](=[O:106])[OH:107])=[O:101])[CH2:18][CH2:17][S:20][CH3:22])=[O:93])[CH2:82][C:83]1[C:91]2[C:86](=[CH:87][CH:88]=[CH:89][CH:90]=2)[NH:85][CH:84]=1)=[O:79])=[O:75])[CH2:72][CH2:71][S:70][CH3:69])=[O:124])[CH2:126][C:12]1[CH:11]=[CH:10][C:9]([OH:15])=[CH:14][CH:13]=1)=[O:140])[CH2:142][C:143](=[O:144])[OH:145]