1,2-Dichloroethane → (4-Bromo-phenyl)-(3-phenyl-piperidin-1-yl)-methanone

HRID 147079Notes

Reaction equation

HRID 147079 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]([C:6](=[O:7])[OH:8])[cH:9][cH:10]1.[CH2:24]([Cl:25])[CH2:26][Cl:27].[CH:38]([N:39]([CH2:40][CH3:41])[CH:42]([CH3:43])[CH3:44])([CH3:45])[CH3:46].[ClH:23].[O:47]=[CH:48][N:49]([CH3:50])[CH3:51].[OH2:52].[OH:28][n:29]1[c:30]2[c:31]([cH:32][cH:33][cH:34][cH:35]2)[n:36][n:37]1.[c:11]1([CH:17]2[CH2:18][NH:19][CH2:20][CH2:21][CH2:22]2)[cH:12][cH:13][cH:14][cH:15][cH:16]1>>[Br:1][c:2]1[cH:3][cH:4][c:5]([C:6](=[O:8])[N:19]2[CH2:18][CH:17]([c:11]3[cH:12][cH:13][cH:14][cH:15][cH:16]3)[CH2:22][CH2:21][CH2:20]2)[cH:9][cH:10]1

Participants

9

Reactant 8

HCID 111,2-DichloroethaneHCID 313Hydrochloric AcidHCID 962WaterHCID 6228DimethylformamideHCID 114644-Bromobenzoic acidHCID 757711-HydroxybenzotriazoleHCID 81531DiisopropylethylamineHCID 1072073-Phenylpiperidine

Product 1

HCID 57849622(4-Bromo-phenyl)-(3-phenyl-piperidin-1-yl)-methanone

Sources & evidence

ORD record
ord-714231357fd641c0bfa6ce43037baa20
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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