Hydrochloric Acid → 1-Ethyl-3-(3-phenylethynylpyrido[2,3-b]pyrazin-6-yl)urea

HRID 151295Notes

Reaction equation

HRID 151295 reaction equation
[CH3:18][CH2:19][N:20]([CH2:21][CH3:22])[CH2:23][CH3:24].[CH3:34][N:35]([CH3:36])[CH:37]=[O:38].[Cl:1][c:2]1[cH:3][n:4][c:5]2[c:6]([n:7]1)[n:8][c:9]([NH:12][C:13](=[O:14])[NH:15][CH2:16][CH3:17])[cH:10][cH:11]2.[Cl:39][CH2:40][Cl:41].[ClH:33].[Cu:42][I:43].[Pd:44]([Cl:45])[Cl:46].[c:25]1([C:31]#[CH:32])[cH:26][cH:27][cH:28][cH:29][cH:30]1.[c:47]1([P:48]([c:49]2[cH:50][cH:51][cH:52][cH:53][cH:54]2)[c:55]2[cH:56][cH:57][cH:58][cH:59][cH:60]2)[cH:61][cH:62][cH:63][cH:64][cH:65]1.[c:66]1([P:67]([c:68]2[cH:69][cH:70][cH:71][cH:72][cH:73]2)[c:74]2[cH:75][cH:76][cH:77][cH:78][cH:79]2)[cH:80][cH:81][cH:82][cH:83][cH:84]1>>[c:2]1([C:32]#[C:31][c:25]2[cH:26][cH:27][cH:28][cH:29][cH:30]2)[cH:3][n:4][c:5]2[c:6]([n:7]1)[n:8][c:9]([NH:12][C:13](=[O:14])[NH:15][CH2:16][CH3:17])[cH:10][cH:11]2

Participants

10

Reactant 9

HCID 313Hydrochloric AcidHCID 6228DimethylformamideHCID 6344DichloromethaneHCID 8471TriethylamineHCID 10821PhenylacetyleneHCID 11776Triphenylphosphine2×HCID 24290Palladium ChlorideHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 588817911-(3-Chloropyrido[2,3-b]pyrazin-6-yl)-3-ethylurea

Product 1

HCID 166665761-Ethyl-3-(3-phenylethynylpyrido[2,3-b]pyrazin-6-yl)urea

Sources & evidence

ORD record
ord-0eadc7491a32455eb05b4ec8b48a33c5
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

Loading…