Hydrochloric Acid → Tert-butyl 2-(4-methylpiperazin-1-yl)acetate

HRID 152176Notes

Reaction equation

HRID 152176 reaction equation
[Br:17][CH2:18][C:19](=[O:20])[O:21][C:22]([CH3:23])([CH3:24])[CH3:25].[CH2:26]1[O:27][CH2:28][CH2:29][CH2:30]1.[CH3:10][CH2:11][N:12]([CH2:13][CH3:14])[CH2:15][CH3:16].[CH3:31][CH2:32][O:33][C:34]([CH3:35])=[O:36].[CH3:3][N:4]1[CH2:5][CH2:6][NH:7][CH2:8][CH2:9]1.[ClH:1].[ClH:2].[OH2:37]>>[CH3:3][N:4]1[CH2:5][CH2:6][N:7]([CH2:18][C:19](=[O:20])[O:21][C:22]([CH3:23])([CH3:24])[CH3:25])[CH2:8][CH2:9]1

Participants

8

Reactant 7

HCID 313Hydrochloric Acid2×HCID 962WaterHCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 531671-MethylpiperazineHCID 79177tert-Butyl bromoacetate

Product 1

HCID 11816730Tert-butyl 2-(4-methylpiperazin-1-yl)acetate

Sources & evidence

ORD record
ord-86a584dea65a4bd68d147ac76f9d4e40
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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