Hydrochloric Acid → N-(4-cyclopropyl-1,3-thiazol-2-yl)-2-[2-[3-(difluoromethoxy)-2-(2,2-dimethylpropoxy)phenyl]ethenyl]imidazo[1,2-a]pyridine-3-carboxamide

HRID 1541623Notes

Reaction equation

HRID 1541623 reaction equation
[CH2:61]1[O:62][CH2:63][CH2:64][CH2:65]1.[CH3:1][C:2]([CH2:3][O:4][c:5]1[c:6]([CH:15]=[CH:16][c:17]2[n:18][c:19]3[n:20]([cH:21][cH:22][cH:23][cH:24]3)[c:25]2[C:26](=[O:27])[OH:28])[cH:7][cH:8][cH:9][c:10]1[O:11][CH:12]([F:13])[F:14])([CH3:29])[CH3:30].[CH3:40][CH2:41][N:42]=[C:43]=[N:44][CH2:45][CH2:46][CH2:47][N:48]([CH3:49])[CH3:50].[CH3:52][N:53]([c:54]1[cH:55][cH:56][n:57][cH:58][cH:59]1)[CH3:60].[CH:31]1([c:34]2[n:35][c:36]([NH2:39])[s:37][cH:38]2)[CH2:32][CH2:33]1.[ClH:51].[O:66]=[CH:67][N:68]([CH3:69])[CH3:70]>>[CH3:1][C:2]([CH2:3][O:4][c:5]1[c:6]([CH:15]=[CH:16][c:17]2[n:18][c:19]3[n:20]([cH:21][cH:22][cH:23][cH:24]3)[c:25]2[C:26](=[O:28])[NH:39][c:36]2[n:35][c:34]([CH:31]3[CH2:32][CH2:33]3)[cH:38][s:37]2)[cH:7][cH:8][cH:9][c:10]1[O:11][CH:12]([F:13])[F:14])([CH3:29])[CH3:30]

Participants

8

Reactant 7

HCID 313Hydrochloric AcidHCID 6228DimethylformamideHCID 8028TetrahydrofuranHCID 142844-(Dimethylamino)pyridineHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 6744564-Cyclopropyl-1,3-thiazol-2-amineHCID 675491322-[2-[3-(Difluoromethoxy)-2-(2,2-dimethylpropoxy)phenyl]ethenyl]imidazo[1,2-a]pyridine-3-carboxylic acid

Product 1

HCID 75215948N-(4-cyclopropyl-1,3-thiazol-2-yl)-2-[2-[3-(difluoromethoxy)-2-(2,2-dimethylpropoxy)phenyl]ethenyl]imidazo[1,2-a]pyridine-3-carboxamide

Sources & evidence

ORD record
ord-7a600b01f32b42aeb814d891451d9218
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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