Chloride → 2-(1-Benzofuran-2-yl)pyridine

HRID 1552222Notes

Reaction equation

HRID 1552222 reaction equation
[Br:1][c:2]1[o:3][c:4]2[c:5]([cH:6]1)[cH:7][cH:8][cH:9][cH:10]2.[CH2:11]([Sn:12]([CH2:13][CH2:14][CH2:15][CH3:22])([c:16]1[n:17][cH:18][cH:19][cH:20][cH:21]1)[CH2:23][CH2:24][CH2:25][CH3:26])[CH2:27][CH2:28][CH3:29].[Cl-:50].[Cu:56][I:57].[Li+:49].[O:51]=[CH:52][N:53]([CH3:54])[CH3:55].[OH2:135].[c:30]1([P:31]([c:32]2[cH:33][cH:34][cH:35][cH:36][cH:37]2)[c:38]2[cH:39][cH:40][cH:41][cH:42][cH:43]2)[cH:44][cH:45][cH:46][cH:47][cH:48]1.[cH:58]1[cH:59][cH:60][c:61]([P:62]([Pd:63]([P:64]([c:65]2[cH:66][cH:67][cH:68][cH:69][cH:70]2)([c:71]2[cH:72][cH:73][cH:74][cH:75][cH:76]2)[c:77]2[cH:78][cH:79][cH:80][cH:81][cH:82]2)([P:83]([c:84]2[cH:85][cH:86][cH:87][cH:88][cH:89]2)([c:90]2[cH:91][cH:92][cH:93][cH:94][cH:95]2)[c:96]2[cH:97][cH:98][cH:99][cH:100][cH:101]2)[P:102]([c:103]2[cH:104][cH:105][cH:106][cH:107][cH:108]2)([c:109]2[cH:110][cH:111][cH:112][cH:113][cH:114]2)[c:115]2[cH:116][cH:117][cH:118][cH:119][cH:120]2)([c:121]2[cH:122][cH:123][cH:124][cH:125][cH:126]2)[c:127]2[cH:128][cH:129][cH:130][cH:131][cH:132]2)[cH:133][cH:134]1>>[c:2]1(-[c:16]2[n:17][cH:18][cH:19][cH:20][cH:21]2)[o:3][c:4]2[c:5]([cH:6]1)[cH:7][cH:8][cH:9][cH:10]2

Participants

10

Reactant 9

HCID 312ChlorideHCID 962WaterHCID 6228DimethylformamideHCID 11776TriphenylphosphineHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 28486Lithium ionHCID 6077842-(Tributylstannyl)pyridineHCID 27762642-Bromo-1-benzofuranHCID 178420554HCID 178420554, compound

Product 1

HCID 108888282-(1-Benzofuran-2-yl)pyridine

Sources & evidence

ORD record
ord-c06c7c79886045b0a2341b05b8d0f4a0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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