Tetrahydrofuran → HCID 54712201, compound

HRID 1553417Notes

Reaction equation

HRID 1553417 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([OH:22])[c:7]([C:14](=[O:15])[NH:16][CH2:17][C:18](=[O:19])[O:20][CH3:21])[c:8](=[O:13])[n:9]([CH3:12])[c:10]2[cH:11]1.[C:23](#[CH:24])[Si:25]([CH3:26])([CH3:27])[CH3:28].[CH2:29]([N:30]([CH:31]([CH3:32])[CH3:33])[CH:34]([CH3:35])[CH3:36])[CH3:37].[Cu:84][I:85].[O:38]1[CH2:39][CH2:40][CH2:41][CH2:42]1.[Pd:43]([Cl:44])[Cl:45].[c:46]1([P:47]([c:48]2[cH:49][cH:50][cH:51][cH:52][cH:53]2)[c:54]2[cH:55][cH:56][cH:57][cH:58][cH:59]2)[cH:60][cH:61][cH:62][cH:63][cH:64]1.[c:65]1([P:66]([c:67]2[cH:68][cH:69][cH:70][cH:71][cH:72]2)[c:73]2[cH:74][cH:75][cH:76][cH:77][cH:78]2)[cH:79][cH:80][cH:81][cH:82][cH:83]1>>[c:2]1([C:24]#[C:23][Si:25]([CH3:26])([CH3:27])[CH3:28])[cH:3][cH:4][c:5]2[c:6]([OH:22])[c:7]([C:14](=[O:15])[NH:16][CH2:17][C:18](=[O:19])[O:20][CH3:21])[c:8](=[O:13])[n:9]([CH3:12])[c:10]2[cH:11]1

Participants

8

Reactant 7

HCID 8028TetrahydrofuranHCID 11776Triphenylphosphine2×HCID 24290Palladium ChlorideHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 66111TrimethylsilylacetyleneHCID 81531DiisopropylethylamineHCID 54681697Methyl 2-(7-bromo-4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxamido)acetate

Product 1

HCID 54712201HCID 54712201, compound

Sources & evidence

ORD record
ord-4466680f3c6b4bb6a33c9e00203accda
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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