Hydrochloric Acid → N-methoxy-2-(2-{7-[[(2-methoxyphenyl)sulfonyl](methyl)amino]-1H-indol-2-yl}-4,5-dihydro-1,3-thiazol-5-yl)-N-methylacetamide

HRID 155972Notes

Reaction equation

HRID 155972 reaction equation
[CH3:2][NH:3][O:4][CH3:5].[CH3:48][N:49]([CH3:50])[CH2:51][CH2:52][CH2:53][N:54]=[C:55]=[N:56][CH2:57][CH3:58].[CH3:59][N:60]([CH3:61])[CH:62]=[O:63].[CH3:64][CH2:65][O:66][C:67](=[O:68])[CH3:69].[CH3:6][O:7][c:8]1[c:9]([S:14](=[O:15])(=[O:16])[N:17]([c:18]2[cH:19][cH:20][cH:21][c:22]3[cH:23][c:24]([C:27]4=[N:31][CH2:30][CH:29]([CH2:32][C:33](=[O:34])[OH:35])[S:28]4)[nH:25][c:26]23)[CH3:36])[cH:10][cH:11][cH:12][cH:13]1.[CH3:70][CH2:71][N:72]([CH2:73][CH3:74])[CH2:75][CH3:76].[ClH:1].[ClH:47].[n:37]1([OH:38])[c:39]2[cH:40][cH:41][cH:42][cH:43][c:44]2[n:45][n:46]1>>[CH3:2][N:3]([O:4][CH3:5])[C:33]([CH2:32][CH:29]1[S:28][C:27]([c:24]2[cH:23][c:22]3[cH:21][cH:20][cH:19][c:18]([N:17]([S:14]([c:9]4[c:8]([O:7][CH3:6])[cH:13][cH:12][cH:11][cH:10]4)(=[O:15])=[O:16])[CH3:36])[c:26]3[nH:25]2)=[N:31][CH2:30]1)=[O:34]

Participants

9

Reactant 8

HCID 313Hydrochloric Acid2×HCID 6228DimethylformamideHCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 14232N,O-DimethylhydroxylamineHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 757711-HydroxybenzotriazoleHCID 59135901(2-{7-[[(2-methoxyphenyl)sulfonyl](methyl)amino]-1H-indol-2-yl}-4,5-dihydro-1,3-thiazol-5-yl)acetic acid

Product 1

HCID 59135986N-methoxy-2-(2-{7-[[(2-methoxyphenyl)sulfonyl](methyl)amino]-1H-indol-2-yl}-4,5-dihydro-1,3-thiazol-5-yl)-N-methylacetamide

Sources & evidence

ORD record
ord-758434fc369c4db4b6b14ce39183e07c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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