Tetrahydrofuran → 1-Cyclopropyl-6-trimethylsilanylethynyl-4,4-dimethyl-1,2,3,4-tetrahydroquinoline
Reaction equation
[Br:1][c:2]1[cH:3][c:4]2[c:9]([cH:10][cH:11]1)[N:8]([CH:12]1[CH2:13][CH2:14]1)[CH2:7][CH2:6][C:5]2([CH3:15])[CH3:16].[CH2:23]([N:24]([CH2:25][CH3:26])[CH2:27][CH3:28])[CH3:29].[CH3:17][Si:18]([CH3:19])([CH3:20])[C:21]#[CH:22].[Cu:30][I:31].[O:73]1[CH2:74][CH2:75][CH2:76][CH2:77]1.[Pd:32]([Cl:33])[Cl:34].[c:35]1([P:36]([c:37]2[cH:38][cH:39][cH:40][cH:41][cH:42]2)[c:43]2[cH:44][cH:45][cH:46][cH:47][cH:48]2)[cH:49][cH:50][cH:51][cH:52][cH:53]1.[c:54]1([P:55]([c:56]2[cH:57][cH:58][cH:59][cH:60][cH:61]2)[c:62]2[cH:63][cH:64][cH:65][cH:66][cH:67]2)[cH:68][cH:69][cH:70][cH:71][cH:72]1>>[c:2]1([C:22]#[C:21][Si:18]([CH3:17])([CH3:19])[CH3:20])[cH:3][c:4]2[c:9]([cH:10][cH:11]1)[N:8]([CH:12]1[CH2:13][CH2:14]1)[CH2:7][CH2:6][C:5]2([CH3:15])[CH3:16]Participants
8
Reactant 7
Product 1
Sources & evidence
- ORD record
- ord-9361aa072f1b4534993ceb8073d2bf69
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
Loading…