1-Amino-2-propanol → 3-(Benzylamino)propanol

HRID 1608229Notes

Reaction equation

HRID 1608229 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][OH:5].[CH:6](=O)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[NH2:14][CH2:15][CH:16]([CH3:18])[OH:17].Cl[C:20]1[CH:27]=[CH:26][CH:25]=[CH:24][C:21]=1[CH:22]=O>>[CH2:6]([NH:1][CH2:2][CH2:3][CH2:4][OH:5])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[NH2:14][CH2:15][CH:16]1[CH2:18][N:1]([CH2:22][C:21]2[CH:24]=[CH:25][CH:26]=[CH:27][CH:20]=2)[CH2:2][CH2:3][CH2:4][O:17]1

Participants

6

Reactant 4

HCID 41-Amino-2-propanolHCID 240BenzaldehydeHCID 69962-ChlorobenzaldehydeHCID 90863-Amino-1-propanol

Product 2

HCID 784483-(Benzylamino)propanolHCID 104210231-(4-benzyl-1,4-oxazepan-2-yl)methanamine(SALTDATA: FREE)

Procedure

3-Benzylaminopropanol is prepared in substantially the same manner as in Reference Example 72, using 3-aminopropanol and benzaldehyde, respectively, in place of 2-amino-1-methylethanol and 2-chlorobenzaldehyde in Reference Example 72. This product is converted to the oily title compound in substantially the same manner as in Reference Examples 73 to 76.

Sources & evidence

ORD record
ord-a3efbb5e45704e25b79f3ef4b4c0bb8f
Source dataset
uspto-grants-1989_09
Patent number
US04870074

Reaction notes

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