Ammonium → 7-Cyclopentyl-5-hydroxyspiro[chromen-2,1'-cyclobutan]-4(3H)-one

HRID 162390Notes

Reaction equation

HRID 162390 reaction equation
[Br-:26].[CH3:37][CH2:38][O:39][C:40](=[O:41])[CH3:42].[CH3:43][N:44]([CH3:45])[CH:46]=[O:47].[CH:27]1([Zn+:32])[CH2:28][CH2:29][CH2:30][CH2:31]1.[Cl-:25].[Cl-:33].[ClH:36].[F:1][C:2]([F:3])([F:4])[S:5]([O:6][c:7]1[cH:8][c:9]([OH:21])[c:10]2[c:15]([cH:16]1)[O:14][C:13]1([CH2:12][C:11]2=[O:20])[CH2:17][CH2:18][CH2:19]1)(=[O:22])=[O:23].[Li+:24].[NH4+:34].[OH2:35]>>[c:7]1([CH:27]2[CH2:28][CH2:29][CH2:30][CH2:31]2)[cH:8][c:9]([OH:21])[c:10]2[c:15]([cH:16]1)[O:14][C:13]1([CH2:12][C:11]2=[O:20])[CH2:17][CH2:18][CH2:19]1

Participants

11

Reactant 10

HCID 223AmmoniumHCID 259Bromide ionHCID 312Chloride2×HCID 313Hydrochloric AcidHCID 962WaterHCID 6228DimethylformamideHCID 8857Ethyl AcetateHCID 28486Lithium ionHCID 58002968HCID 58002968, compoundHCID 178528063HCID 178528063, compound

Product 1

HCID 580029377-Cyclopentyl-5-hydroxyspiro[chromen-2,1'-cyclobutan]-4(3H)-one

Sources & evidence

ORD record
ord-5e57720ed0024c47b13dbcba44a3eb14
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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