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HRID1642067

反应详情

EQUATION

反应方程式

HRID 1642067 的结构方程式

REACTANTS

反应物

4
结构：Cl
HCID313

Hydrochloric Acid

ClH

结构：CC(C)NC(C)C
HCID7912

Diisopropylamine

C6H15N

结构：O=[N+]([O-])c1ccccc1I
HCID69115

Benzene, 1-iodo-2-nitro-

C6H4INO2

结构：C#CP(=O)(OCC)OCC
HCID2784295

diethyl ethynylphosphonate

C6H11O3P

PRODUCTS

生成物

1
结构：CCOP(=O)(C#Cc1ccccc1[N+](=O)[O-])OCC
HCID86638334

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

4
结构：[Cu][I]
催化剂HCID24350

Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)

CuI

结构：[Cl][Pd][Cl].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1
催化剂HCID6102075

未命名化合物

结构：C1CCOC1
溶剂HCID8028

Tetrahydrofuran

C4H8O

结构：CCOC(C)=O
溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

To a solution of 300 mg of ethynyl-phosphonic acid diethyl ester, 494 mg of 1-iodo-2-nitrobenzene and 0.28 ml of di-isopropylamine in 15 ml THF are sequentially added 43 mg of bis-(triphenylphosphin)-palladium(II)-dichloride and 12 mg of copper(I)iodide and the mixture obtained is refluxed for approximately 2 hours. Following an acidic work-up (1N aqueous HCl and EtOAc) and subsequent column chromatography (2-nitro-phenylethynyl)-phosphonic acid diethyl ester is obtained in the form of a slightly brownish oil.

WORKUP

后处理

  1. customthe mixture obtained
  2. temperatureis refluxed for approximately 2 hours