Pyridine → Diisopropylethylamine

HRID 1644673Notes

Reaction equation

HRID 1644673 reaction equation
[CH2:1](N(CC)CC)[CH3:2].N1[CH:13]=[CH:12][CH:11]=CC=1.Cl[CH2:15]Cl.[C:17](#[N:19])[CH3:18]>O1CCCC1.CN(C=O)C.O1CCOCC1>[CH:17]([N:19]([CH:12]([CH3:11])[CH3:13])[CH2:1][CH3:2])([CH3:15])[CH3:18]

Participants

8

Reactant 4

HCID 1049PyridineHCID 6342AcetonitrileHCID 6344DichloromethaneHCID 8471Triethylamine

Product 1

HCID 81531Diisopropylethylamine

Reagents, catalysts & solvents 3

HCID 6228DimethylformamideSolventHCID 8028TetrahydrofuranSolventHCID 312751,4-DioxaneSolvent

Procedure

Carbamates XX can be obtained through a reaction of compound XVIII with XIX (R′=tert-butyl) in the presence of an amine base such as diisopropylethylamine, triethylamine or pyridine in a suitable inert solvent such as dichloromethane, acetonitrile, 1,4-dioxane, N,N,-dimethylformamide, tetrahydrofuran, or mixtures thereof, at 0° C. to room temperature for several hours.

Sources & evidence

ORD record
ord-d1400ad0c0604239a472ef60b478e03f
Source dataset
uspto-grants-2012_02
Patent number
US08124629B2

Reaction notes

Loading…