Potassium Carbonate → HCID 19918922, compound

HRID 1648206Notes

Reaction equation

HRID 1648206 reaction equation
[OH:1][C:2]1[CH:11]=[C:10]([CH3:12])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.Br[C:14]1[CH:18]=[CH:17][S:16][CH:15]=1.C(=O)([O-])[O-].[K+].[K+].IC1C=CC=CC=1>CN(C=O)C.C(OCC)(=O)C.O>[CH3:12][C:10]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]([C:14]2[CH:18]=[CH:17][S:16][CH:15]=2)[C:2](=[O:1])[CH:11]=1

Participants

8

Reactant 4

HCID 11430Potassium CarbonateHCID 11575IodobenzeneHCID 133833-BromothiopheneHCID 178429252HCID 178429252, compound

Product 1

HCID 19918922HCID 19918922, compound

Reagents, catalysts & solvents 3

HCID 962WaterSolventHCID 6228DimethylformamideSolventHCID 8857Ethyl AcetateSolvent

Procedure

A mixture of 0.8 g of 2-hydroxy-4-methylquinoline, 1.22 g of 3-bromothiophene, 0.69 g of potassium carbonate and 1.9 g of iodobenzene in 10 mL of DMF is heated to reflux for 16 hours. The reaction is worked up with water and ethyl acetate and the desired product is isolated by column chromatography.

Workup

  1. temperatureis heated
  2. temperatureto reflux for 16 hours

Sources & evidence

ORD record
ord-8cb2c1d57682400fb635cb2e43f6fdc2
Source dataset
uspto-grants-1995_07
Patent number
US05436134

Reaction notes

Loading…