4-Methylmorpholine → 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide

HRID 1711121Notes

Reaction equation

HRID 1711121 reaction equation
O.ON1C2C=CC=CC=2N=N1.C(N(C(C)C)CC)(C)C.CN1CCOCC1.Cl.[CH3:29][N:30]([CH3:39])[CH2:31][CH2:32][CH2:33][N:34]=[C:35]=[N:36][CH2:37][CH3:38]>C(Cl)Cl.CN(C=O)C>[CH3:38][CH2:37][N:36]=[C:35]=[N:34][CH2:33][CH2:32][CH2:31][N:30]([CH3:39])[CH3:29]

Participants

7

Reactant 4

HCID 79724-MethylmorpholineHCID 81531DiisopropylethylamineHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 27960291-Hydroxybenzotriazole hydrate

Product 1

HCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 6344DichloromethaneSolvent

Procedure

To a stirred solution of a primary or secondary amine (1 equivalent), a carboxylic acid (1.1-2.0 equivalents), 1-hydroxy-benzotriazole hydrate (HOBT) (1.1-2.0 equivalents) and diisopropylethylamine (DIPEA) or N-methylmorpholine (NMM) (1.5-3 equivalents) in CH2Cl2 or DMF (concentration ˜0.05-1.5M) was added 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride (EDCI) (1.1-2.0 equivalents). The solution was stirred at room temperature for 1-3 days and concentrated in vacuo. In a standard work-up, the mixture was diluted with CH2Cl2 or EtOAc and washed consecutively with saturated aqueous NaHCO3 and brine. The organic layer was dried (Na2SO4 or mgSO4), filtered and concentrated under reduced pressure. The crude material was purified by flash column chromatography or by radial chromatography on silica gel.

Workup

  1. concentrationconcentrated in vacuo
  2. additionIn a standard work-up, the mixture was diluted with CH2Cl2 or EtOAc
  3. washwashed consecutively with saturated aqueous NaHCO3 and brine
  4. dry with materialThe organic layer was dried (Na2SO4 or mgSO4)
  5. filtrationfiltered
  6. concentrationconcentrated under reduced pressure
  7. customThe crude material was purified by flash column chromatography or by radial chromatography on silica gel

Sources & evidence

ORD record
ord-596bd56972334de284805c632b9db68a
Source dataset
uspto-grants-2010_09
Patent number
US07790747B2

Reaction notes

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