Ethylparaben → HCID 22225393, compound

HRID 1744808Notes

Reaction equation

HRID 1744808 reaction equation
[OH:1][C:2]1[CH:12]=[CH:11][C:5]([C:6]([O:8][CH2:9][CH3:10])=[O:7])=[CH:4][CH:3]=1.[H-].[Na+].[Na].[CH2:16]([NH:23][C:24](=[O:47])[C:25]1[CH:30]=[CH:29][C:28]([N:31]2[C:36]3[N:37]=[C:38](S(C)(=O)=O)[N:39]=[C:40]([CH3:41])[C:35]=3[CH:34]=[CH:33][C:32]2=[O:46])=[CH:27][CH:26]=1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>C1COCC1>[CH2:16]([NH:23][C:24]([C:25]1[CH:26]=[CH:27][C:28]([N:31]2[C:36]3[N:37]=[C:38]([O:1][C:2]4[CH:3]=[CH:4][C:5]([C:6]([O:8][CH2:9][CH3:10])=[O:7])=[CH:11][CH:12]=4)[N:39]=[C:40]([CH3:41])[C:35]=3[CH:34]=[CH:33][C:32]2=[O:46])=[CH:29][CH:30]=1)=[O:47])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Participants

6

Reactant 4

HCID 8434EthylparabenHCID 24758Sodium hydrideHCID 5360545SodiumHCID 22225250HCID 22225250, compound

Product 1

HCID 22225393HCID 22225393, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

Ethyl 4-hydroxybenzoate (0.128 mmol) was suspended in THF (1 ml) and NaH (2.9 mg, 0.12 mmol) was added. After formation of the subsequent sodium salt, suspended in THF, the resin (A3) was added and shaking continued for 18 h. The resin was washed with THF (2×1 min), DMF (3×1 min, 60° C.) and with DCM (3×1 min).

Workup

  1. washThe resin was washed with THF (2×1 min), DMF (3×1 min, 60° C.) and with DCM (3×1 min)

Sources & evidence

ORD record
ord-9977de3dd4974e1ba08fa92e0bcfd497
Source dataset
uspto-grants-2006_03
Patent number
US07019002B2

Reaction notes

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