反应详情

A mixture of 0.10 g of 5-trifluoromethylsulfinylbenzoxazole, 0.15 g of 1-bromo-2-ethylsulfanyl-4-trifluoromethylsulfanylbenzene, 0.01 g of palladium(II) acetate, 0.01 g of triphenylphosphine, 0.02 g of copper(II) acetate monohydrate, 0.13 g of potassium carbonate and 3 ml of toluene was stirred under heating and refluxing for 2 hours. Ethyl acetate and water were added to the cooled reaction mixture, and the mixture was extracted with ethyl acetate and then dried with anhydrous sodium sulfate. The residue obtained by concentrating the mixture under reduced pressure was applied to a silica gel column chromatography to obtain 0.03 g of 2-(2-ethylsulfanyl-4-trifluoromethylsulfanyl-phenyl)-5-trifluoromethylsulfanylbenzoxazole (hereinafter, referred to as Compound 19).

1. temperatureunder heating
2. temperaturerefluxing for 2 hours
3. extractionthe mixture was extracted with ethyl acetate
4. dry with materialdried with anhydrous sodium sulfate
5. customThe residue obtained
6. concentrationby concentrating the mixture under reduced pressure