Hydrochloric Acid → HCID 25140485, compound

HRID 1750735Notes

Reaction equation

HRID 1750735 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH2:13][CH2:12][CH2:11][CH2:10][C:9]=2[CH2:14][N:15]2[CH2:20][CH2:19][N:18]([C:21]3[CH:31]=[CH:30][C:24]([C:25]([O:27]CC)=[O:26])=[CH:23][CH:22]=3)[CH2:17][CH2:16]2)=[CH:4][CH:3]=1.O.[OH-].[Li+].Cl>O1CCCC1.CO.O.C(OCC)(=O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH2:13][CH2:12][CH2:11][CH2:10][C:9]=2[CH2:14][N:15]2[CH2:16][CH2:17][N:18]([C:21]3[CH:22]=[CH:23][C:24]([C:25]([OH:27])=[O:26])=[CH:30][CH:31]=3)[CH2:19][CH2:20]2)=[CH:4][CH:3]=1

Participants

8

Reactant 3

HCID 313Hydrochloric AcidHCID 168937Lithium hydroxide, monohydrateHCID 25140337HCID 25140337, compound

Product 1

HCID 25140485HCID 25140485, compound

Reagents, catalysts & solvents 4

HCID 887MethanolSolventHCID 962WaterSolventHCID 8028TetrahydrofuranSolventHCID 8857Ethyl AcetateSolvent

Procedure

To a solution of Example 8E (254 mg, 0.457 mmol) in tetrahydrofuran (4 mL), methanol (2 mL) and water (2 mL) was added lithium hydroxide monohydrate (126 mg, 3 mmol). The mixture was stirred at room temperature overnight. The mixture was then neutralized with 5% HCl and diluted with ethyl acetate (200 mL). After washing with brine, it was dried over Na2SO4. Evaporation of solvent gave title compound.

Workup

  1. washAfter washing with brine, it
  2. dry with materialwas dried over Na2SO4
  3. customEvaporation of solvent

Sources & evidence

ORD record
ord-b861856677e544858f6e8a532d9a3fa2
Source dataset
uspto-grants-2015_10
Patent number
US09156856B2

Reaction notes

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