Ammonia → N-[1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-5-methyl-1,3,4-oxadiazole-2-carboxamide

HRID 178482Notes

Reaction equation

HRID 178482 reaction equation
[CH2:57]1[O:58][CH2:59][CH2:60][CH2:61]1.[CH3:1][c:2]1[n:3][n:4][c:5]([C:7](=[O:8])[O-:9])[o:6]1.[CH3:62][CH2:63][O:64][C:65]([CH3:66])=[O:67].[CH3:68][C:69]#[N:70].[CH:46]([N:47]([CH2:48][CH3:49])[CH:50]([CH3:51])[CH3:52])([CH3:53])[CH3:54].[Cl-:55].[Cl:11][C:12]([C:13]([Cl:14])=[O:15])=[O:16].[F:17][c:18]1[cH:19][cH:20][c:21](-[n:24]2[n:25][cH:26][c:27]3[cH:28][c:29]([O:33][CH:34]([CH:35]([CH3:36])[NH2:37])[c:38]4[cH:39][c:40]([O:44][CH3:45])[cH:41][cH:42][cH:43]4)[cH:30][cH:31][c:32]23)[cH:22][cH:23]1.[K+:10].[NH3:56]>>[CH3:1][c:2]1[n:3][n:4][c:5]([C:7](=[O:9])[NH:37][CH:35]([CH:34]([O:33][c:29]2[cH:28][c:27]3[cH:26][n:25][n:24](-[c:21]4[cH:20][cH:19][c:18]([F:17])[cH:23][cH:22]4)[c:32]3[cH:31][cH:30]2)[c:38]2[cH:39][c:40]([O:44][CH3:45])[cH:41][cH:42][cH:43]2)[CH3:36])[o:6]1

Participants

11

Reactant 10

HCID 222AmmoniaHCID 312ChlorideHCID 813Potassium CationHCID 6342AcetonitrileHCID 8028TetrahydrofuranHCID 8857Ethyl AcetateHCID 65578Oxalyl chlorideHCID 81531DiisopropylethylamineHCID 404282915-Methyl-1,3,4-oxadiazole-2-carboxylateHCID 690532851-[1-(4-Fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-amine

Product 1

HCID 75038950N-[1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-5-methyl-1,3,4-oxadiazole-2-carboxamide

Sources & evidence

ORD record
ord-e55ebe1aae174868a57ce34b22622ce4
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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