反应详情

温度

120 °C

278 μL (2 mmol) 1-bromonaphthaline, 20 mg (0.2 mmol) copper(I) chloride, 550 mg (4 mmol) potassium carbonate, 260 mg (2.4 mmol) o-cresol, 130 μL 1-butylimidazole, 2 mL toluene and 200 μL internal standard (tetradecane) were added to an Ace pressure tube under argon and heated to 120° C. for 16 h. After cooling, water and diethyl ether were added, the organic phase was washed with 10% K2CO3 solution, water and brine and dried over Na2SO4. GC analysis of the organic phase showed a yield of 89%. After evaporation of the solvents, the dark brown oil was submitted to column chromatography over silica gel, eluent light petroleum. 0.38 g of colourless oil was recovered (81% isolated yield). The substance was identified by gc/ms and nmr spectroscopy.

1. temperatureAfter cooling
2. washthe organic phase was washed with 10% K2CO3 solution, water and brine
3. dry with materialdried over Na2SO4
4. customAfter evaporation of the solvents
5. custom0.38 g of colourless oil was recovered
6. custom(81% isolated yield)