Hydrochloric Acid → 8-Benzyl-2-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-1-phenyl-8-azabicyclo[3.2.1]octane-6-carbohydrazide

HRID 191800Notes

Reaction equation

HRID 191800 reaction equation
[CH2:8]([c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1)[N:15]1[C:16]2([c:42]3[cH:43][cH:44][cH:45][cH:46][cH:47]3)[CH:17]([O:26][CH2:27][c:28]3[cH:29][c:30]([C:38]([F:39])([F:40])[F:41])[cH:31][c:32]([C:34]([F:35])([F:36])[F:37])[cH:33]3)[CH2:18][CH2:19][CH:20]1[CH:21]([C:23](=[O:24])[OH:25])[CH2:22]2.[CH3:48][CH2:49][N:50]([CH2:51][CH3:52])[CH2:53][CH3:54].[CH3:56][N:57]([CH3:58])[CH2:59][CH2:60][CH2:61][N:62]=[C:63]=[N:64][CH2:65][CH3:66].[CH3:69][CH2:70][O:71][C:72](=[O:73])[CH3:74].[Cl:75][CH2:76][Cl:77].[ClH:55].[F:1][C:2]([F:3])([F:4])[C:5]([OH:6])=[O:7].[NH2:67][NH2:68]>>[CH2:8]([c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1)[N:15]1[C:16]2([c:42]3[cH:43][cH:44][cH:45][cH:46][cH:47]3)[CH:17]([O:26][CH2:27][c:28]3[cH:29][c:30]([C:38]([F:39])([F:40])[F:41])[cH:31][c:32]([C:34]([F:35])([F:36])[F:37])[cH:33]3)[CH2:18][CH2:19][CH:20]1[CH:21]([C:23](=[O:25])[NH:67][NH2:68])[CH2:22]2

Participants

9

Reactant 8

HCID 313Hydrochloric AcidHCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 9321HydrazineHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 879498388-Benzyl-2-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-1-phenyl-8-azabicyclo[3.2.1]octane-6-carboxylic acid

Product 1

HCID 880393898-Benzyl-2-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-1-phenyl-8-azabicyclo[3.2.1]octane-6-carbohydrazide

Sources & evidence

ORD record
ord-d0879b31219046b2896ca188d4bc7584
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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