反应详情

温度

85 °C

4-Bromo-1H-indole-2-carboxylic acid (5 g, 20.8 mmol) and 4-methoxy-phenyl-boronic acid (3.2 g, 20.8 mmol) are dissolved in 1-propanol (100 ml) and the mixture is flushed with argon for 30 min. Then bis(triphenylphosphin)palladium(II)chloride (200 mg, 1 mmol) and Na2CO3 (4.4 g, 40.2 mmol) are added and the reaction mixture is stirred at 85° C. for 3 h. After cooling down to room temperature, ethyl acetate and 2M HCl are added. The organic layers are dried over sodium sulphate. Evaporation gave 6 g of an beige solide, which is further purified by crystallisation from ethyl acetate.

1. customthe mixture is flushed with argon for 30 min
2. temperatureAfter cooling down to room temperature
3. dry with materialThe organic layers are dried over sodium sulphate
4. customEvaporation
5. customgave 6 g of an beige solide, which
6. customis further purified by crystallisation from ethyl acetate