Chloride → 6'-Bromo-4-(difluoromethyl)spiro[cyclohexane-1,2'-inden]-1'(3'H)-one
Reaction equation
[Br:1][c:2]1[cH:3][c:4]([I:22])[c:5]([CH2:6][C:7]2([C:16](=[O:17])[O:18][CH3:19])[CH2:8][CH2:9][CH:10]([CH:13]([F:14])[F:15])[CH2:11][CH2:12]2)[cH:20][cH:21]1.[CH2:32]1[O:33][CH2:34][CH2:35][CH2:36]1.[CH:28]([Mg+:29])([CH3:30])[CH3:31].[Cl-:25].[Cl-:27].[Li+:26].[N:23]#[N:24]>>[Br:1][c:2]1[cH:3][c:4]2[c:5]([cH:20][cH:21]1)[CH2:6][C:7]1([CH2:8][CH2:9][CH:10]([CH:13]([F:14])[F:15])[CH2:11][CH2:12]1)[C:16]2=[O:17]Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-85b5126aec224c2c8a404d22039aafbf
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (6/10)
Reaction notes
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