Hydrochloric Acid → N-(2-{5-[2-(4-hydroxypiperidino)-2-oxoethyl]-4,5-dihydro-1,3-thiazol-2-yl}-1H-indol-7-yl)-2-methoxy-N-methylbenzenesulfonamide

HRID 197416Notes

Reaction equation

HRID 197416 reaction equation
[CH3:1][O:2][c:3]1[c:4]([S:9](=[O:10])(=[O:11])[N:12]([c:13]2[cH:14][cH:15][cH:16][c:17]3[cH:18][c:19]([C:22]4=[N:26][CH2:25][CH:24]([CH2:27][C:28](=[O:29])[OH:30])[S:23]4)[nH:20][c:21]23)[CH3:31])[cH:5][cH:6][cH:7][cH:8]1.[CH3:50][N:51]([CH3:52])[CH2:53][CH2:54][CH2:55][N:56]=[C:57]=[N:58][CH2:59][CH3:60].[CH3:61][CH2:62][O:63][C:64](=[O:65])[CH3:66].[CH3:67][N:68]([CH3:69])[CH:70]=[O:71].[ClH:49].[OH:32][CH:33]1[CH2:34][CH2:35][NH:36][CH2:37][CH2:38]1.[n:39]1([OH:40])[c:41]2[cH:42][cH:43][cH:44][cH:45][c:46]2[n:47][n:48]1>>[CH3:1][O:2][c:3]1[c:4]([S:9](=[O:10])(=[O:11])[N:12]([c:13]2[cH:14][cH:15][cH:16][c:17]3[cH:18][c:19]([C:22]4=[N:26][CH2:25][CH:24]([CH2:27][C:28](=[O:30])[N:36]5[CH2:35][CH2:34][CH:33]([OH:32])[CH2:38][CH2:37]5)[S:23]4)[nH:20][c:21]23)[CH3:31])[cH:5][cH:6][cH:7][cH:8]1

Participants

8

Reactant 7

HCID 313Hydrochloric AcidHCID 6228DimethylformamideHCID 8857Ethyl AcetateHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 757711-HydroxybenzotriazoleHCID 79341Piperidin-4-olHCID 59135901(2-{7-[[(2-methoxyphenyl)sulfonyl](methyl)amino]-1H-indol-2-yl}-4,5-dihydro-1,3-thiazol-5-yl)acetic acid

Product 1

HCID 59135691N-(2-{5-[2-(4-hydroxypiperidino)-2-oxoethyl]-4,5-dihydro-1,3-thiazol-2-yl}-1H-indol-7-yl)-2-methoxy-N-methylbenzenesulfonamide

Sources & evidence

ORD record
ord-989fb82ee9e24868a048ae933c4123fc
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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