5-Bromo-2,4-dichloropyrimidine → HCID 178451804, compound

HRID 2018861Notes

Reaction equation

HRID 2018861 reaction equation
[Cl:1][c:2]1[n:8][c:7](Cl)[c:5]([Br:6])[cH:4][n:3]1.[CH3:9][C:10]([O:13][C:14]([N:16]1[CH2:21][CH:20]=[C:19](B2OC(C)(C)C(C)(C)O2)[CH2:18][CH2:17]1)=[O:15])([CH3:12])[CH3:11]>>[CH3:9][C:10]([O:13][C:14]([N:16]1[CH2:21][CH:20]=[C:19]([c:7]2[c:5]([Br:6])[cH:4][n:3][c:2]([Cl:1])[n:8]2)[CH2:18][CH2:17]1)=[O:15])([CH3:12])[CH3:11]

Participants

7

Reactant 2

HCID 2899735-Bromo-2,4-dichloropyrimidineHCID 4642098Tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridine-1-carboxylate

Product 1

HCID 178451804HCID 178451804, compound

Reagents, catalysts & solvents 4

HCID 516892Sodium BicarbonateReagentHCID 6102075Dichlorobis(triphenylphosphine)palladiumCatalystHCID 6228DimethylformamideSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
70 °C

Sources & evidence

ORD record
ord-b0d5b6e7e01c4a8eb215d068185e0028
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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