Dimethylformamide → 1-(4-Methyl-5-trimethylsilanylethynyl-thiophen-2-yl)-ethanone

HRID 207470Notes

Reaction equation

HRID 207470 reaction equation
[Br:7][c:8]1[c:9]([CH3:16])[cH:10][c:11]([C:13]([CH3:14])=[O:15])[s:12]1.[CH3:17][CH2:18][N:19]([CH2:20][CH3:21])[CH2:22][CH3:23].[CH3:1][Si:2]([CH3:3])([CH3:4])[C:5]#[CH:6].[Cu:70][I:71].[O:24]=[CH:25][N:26]([CH3:27])[CH3:28].[Pd:29]([Cl:30])[Cl:31].[c:32]1([P:33]([c:34]2[cH:35][cH:36][cH:37][cH:38][cH:39]2)[c:40]2[cH:41][cH:42][cH:43][cH:44][cH:45]2)[cH:46][cH:47][cH:48][cH:49][cH:50]1.[c:51]1([P:52]([c:53]2[cH:54][cH:55][cH:56][cH:57][cH:58]2)[c:59]2[cH:60][cH:61][cH:62][cH:63][cH:64]2)[cH:65][cH:66][cH:67][cH:68][cH:69]1>>[CH3:1][Si:2]([CH3:3])([CH3:4])[C:5]#[C:6][c:8]1[c:9]([CH3:16])[cH:10][c:11]([C:13]([CH3:14])=[O:15])[s:12]1

Participants

8

Reactant 7

HCID 6228DimethylformamideHCID 8471TriethylamineHCID 11776Triphenylphosphine2×HCID 24290Palladium ChlorideHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 66111TrimethylsilylacetyleneHCID 454803531-(5-Bromo-4-methylthiophen-2-yl)ethan-1-one

Product 1

HCID 674301401-(4-Methyl-5-trimethylsilanylethynyl-thiophen-2-yl)-ethanone

Sources & evidence

ORD record
ord-7106671e951740ba86e6d39ec624b5b6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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