反应详情

The mixture of 4-chloro-1-iodo-2-(trifluoromethyl)-benzene (15 g), methyl acrylate (6.74 g), tetrabutylammonium chloride (14 g), palladium acetate (0.22 g) and potassium carbonate (13.6 g) in DMF (150 ml) was stirred at room temperature for 4 days. After diluting with ether (1 L), the mixture was washed with water (5×200 ml), then dried over sodium sulphate and solvent removed under reduced pressure. The residue was columned on silica gel using 5:1 heptane:EtOAc as eluant to give (E)-methyl 3-(4-chloro-2-(trifluoromethyl)-phenyl)-acrylate (13 g).

1. washthe mixture was washed with water (5×200 ml)
2. dry with materialdried over sodium sulphate and solvent
3. customremoved under reduced pressure