Hydrochloric Acid → HCID 23159927, compound

A mixture of 3-(4-fluorophenyl)-1H-pyrazole-4-carbaldehyde (190 mg, 1.00 mmol), sodium hydride (60% in oil, 40 mg, 1.00 mmol) and N,N-dimethylformamide (5 mL) was stirred at room temperature for 1 hr. Methyl 3-(4-{[4-(chloromethyl)benzyl]oxy}phenyl)propanoate (318 mg, 1.00 mmol) was added to the reaction mixture at room temperature, and the mixture was further stirred for 1 hr. The reaction mixture was poured into 1 N hydrochloric acid, and the mixture was extracted with ethyl acetate. The ethyl acetate layer was dried using a Presep Dehydration tube (Manufactured by Wako Pure Chemical Industries, Ltd.), and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=19:1-1:1) to give a yellow oil. The oil was dissolved in N,N-dimethylformamide (5 mL), benzyltriphenylphosphonium bromide (660 mg, 1.52 mmol) and potassium carbonate (276 mg, 2.00 mmol) were added, and the mixture was stirred at room temperature for 12 hr. The reaction mixture was poured into 1 N hydrochloric acid, and the mixture was extracted with ethyl acetate. The ethyl acetate layer was concentrated under reduced pressure to give a yellow oil. The yellow oil was dissolved in a mixed solvent of tetrahydrofuran (20 mL) and methanol (20 mL), and platinum oxide (50 mg) was added. The mixture was stirred under an atmospheric hydrogen atmosphere at room temperature for 2 hr. The platinum catalyst was filtered off, and the filtrate was concentrated under reduced pressure. The residue was purified by HPLC (gradient cycle A) to give a colorless oil. The colorless oil was dissolved in a mixed solvent of methanol (5 mL) and tetrahydrofuran (5 mL), and 2 N sodium hydroxide aqueous solution (2 mL) was added. The mixture was stirred at room temperature for 1 hr. The reaction mixture was diluted with water, and neutralized with 1 N hydrochloric acid, and the mixture was extracted with ethyl acetate. The ethyl acetate layer was dried using a Presep Dehydration tube (Manufactured by Wako Pure Chemical Industries, Ltd.), and concentrated under reduced pressure to give the title compound (86 mg, yield 16%) as a colorless oil. MS: m/z 535 (MH+), 1H NMR (CDCl3) δ: 2.66 (2H, t, J=7.6 Hz), 2.76-2.95 (6H, m), 5.05 (2H, s), 5.39 (2H, s), 6.90 (2H, d, J=8.7 Hz), 7.03-7.26 (12H, m), 7.41-7.53 (4H, m).

1. stirringthe mixture was further stirred for 1 hr
2. extractionthe mixture was extracted with ethyl acetate
3. dry with materialThe ethyl acetate layer was dried
4. concentrationconcentrated under reduced pressure
5. customThe residue was purified by silica gel column chromatography (hexane:ethyl acetate=19:1-1:1)
6. customto give a yellow oil
7. stirringthe mixture was stirred at room temperature for 12 hr
8. extractionthe mixture was extracted with ethyl acetate
9. concentrationThe ethyl acetate layer was concentrated under reduced pressure
10. customto give a yellow oil
11. additionwas added
12. stirringThe mixture was stirred under an atmospheric hydrogen atmosphere at room temperature for 2 hr
13. filtrationThe platinum catalyst was filtered off
14. concentrationthe filtrate was concentrated under reduced pressure
15. customThe residue was purified by HPLC (gradient cycle A)
16. customto give a colorless oil
17. additionwas added
18. stirringThe mixture was stirred at room temperature for 1 hr
19. extractionthe mixture was extracted with ethyl acetate
20. dry with materialThe ethyl acetate layer was dried
21. concentrationconcentrated under reduced pressure

ORD record

ord-4a1f6259402a450dbf21218e2609766f

Source dataset

uspto-grants-2009_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07517910B2