Tetrahydrofuran → 2-Bromo-5-phenylethynyl-pyrazine

HRID 2144725Notes

Reaction equation

HRID 2144725 reaction equation
[Br:1][c:2]1[n:3][cH:4][c:5]([I:8])[n:6][cH:7]1.[CH2:43]1[O:44][CH2:45][CH2:46][CH2:47]1.[CH3:17][CH2:18][N:19]([CH2:20][CH3:21])[CH2:22][CH3:23].[CH3:48][CH2:49][O:50][C:51](=[O:52])[CH3:53].[Cu:54][I:55].[c:24]1([P:25]([c:26]2[cH:27][cH:28][cH:29][cH:30][cH:31]2)[c:32]2[cH:33][cH:34][cH:35][cH:36][cH:37]2)[cH:38][cH:39][cH:40][cH:41][cH:42]1.[c:9]1([C:15]#[CH:16])[cH:10][cH:11][cH:12][cH:13][cH:14]1>>[Br:1][c:2]1[n:3][cH:4][c:5]([C:16]#[C:15][c:9]2[cH:10][cH:11][cH:12][cH:13][cH:14]2)[n:6][cH:7]1

Participants

8

Reactant 7

HCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 10821PhenylacetyleneHCID 11776TriphenylphosphineHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 219312002-Bromo-5-iodopyrazine

Product 1

HCID 575167832-Bromo-5-phenylethynyl-pyrazine

Sources & evidence

ORD record
ord-eb1ac97256d24a9b8a440be3cbbf6d10
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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