Hydrochloric Acid → 2-{2-[5-{[6-(Methoxymethyl)pyridin-3-yl]oxy}-7-(tetrahydro-2H-pyran-4-yloxy)-1H-indol-2-yl]-4,5-dihydro-1,3-thiazol-5-yl}-N-methylacetamide

HRID 2144979Notes

Reaction equation

HRID 2144979 reaction equation
[CH3:1][O:2][CH2:3][c:4]1[cH:5][cH:6][c:7]([O:10][c:11]2[cH:12][c:13]3[cH:14][c:15]([C:27]4=[N:31][CH2:30][CH:29]([CH2:32][C:33](=[O:34])[OH:35])[S:28]4)[nH:16][c:17]3[c:18]([O:20][CH:21]3[CH2:22][CH2:23][O:24][CH2:25][CH2:26]3)[cH:19]2)[cH:8][n:9]1.[CH3:37][N:38]([CH3:39])[CH2:40][CH2:41][CH2:42][N:43]=[C:44]=[N:45][CH2:46][CH3:47].[CH3:59][NH2:60].[CH3:62][N:63]([CH3:64])[CH:65]=[O:66].[CH3:67][CH2:68][N:69]([CH2:70][CH3:71])[CH2:72][CH3:73].[ClH:36].[ClH:58].[OH2:61].[OH:48][n:49]1[c:50]2[cH:51][cH:52][cH:53][cH:54][c:55]2[n:56][n:57]1>>[CH3:1][O:2][CH2:3][c:4]1[cH:5][cH:6][c:7]([O:10][c:11]2[cH:12][c:13]3[cH:14][c:15]([C:27]4=[N:31][CH2:30][CH:29]([CH2:32][C:33](=[O:35])[NH:38][CH3:37])[S:28]4)[nH:16][c:17]3[c:18]([O:20][CH:21]3[CH2:22][CH2:23][O:24][CH2:25][CH2:26]3)[cH:19]2)[cH:8][n:9]1

Participants

9

Reactant 8

HCID 313Hydrochloric Acid2×HCID 962WaterHCID 6228DimethylformamideHCID 6329MethylamineHCID 8471TriethylamineHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 757711-HydroxybenzotriazoleHCID 66726112{2-[5-{[6-(Methoxymethyl)pyridin-3-yl]oxy}-7-(tetrahydro-2H-pyran-4-yloxy)-1H-indol-2-yl]-4,5-dihydro-1,3-thiazol-5-yl}acetic acid

Product 1

HCID 667259322-{2-[5-{[6-(Methoxymethyl)pyridin-3-yl]oxy}-7-(tetrahydro-2H-pyran-4-yloxy)-1H-indol-2-yl]-4,5-dihydro-1,3-thiazol-5-yl}-N-methylacetamide

Sources & evidence

ORD record
ord-47d7fec54d074f40a574f661e3ae1924
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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