Hydrochloric Acid → tert-butyl N-[1-(5,6-dihydro-4H-imidazo[1,2-a][1]benzazepin-4-ylcarbamoyl)cyclopropyl]carbamate

HRID 2150243Notes

Reaction equation

HRID 2150243 reaction equation
[C:16]([CH3:17])([CH3:18])([CH3:19])[O:20][C:21](=[O:22])[NH:23][C:24]1([C:27](=[O:28])[OH:29])[CH2:25][CH2:26]1.[CH3:41][N:42]([CH3:43])[CH2:44][CH2:45][CH2:46][N:47]=[C:48]=[N:49][CH2:50][CH3:51].[CH3:66][CH2:67][O:68][C:69](=[O:70])[CH3:71].[CH:52]([N:53]([CH:54]([CH3:55])[CH3:56])[CH2:57][CH3:58])([CH3:59])[CH3:60].[ClH:40].[O:61]1[CH2:62][CH2:63][CH2:64][CH2:65]1.[OH:30][n:31]1[c:32]2[cH:33][cH:34][cH:35][cH:36][c:37]2[n:38][n:39]1.[cH:1]1[cH:2][n:3][c:4]2[n:5]1-[c:6]1[c:7]([cH:12][cH:13][cH:14][cH:15]1)[CH2:8][CH2:9][CH:10]2[NH2:11]>>[cH:1]1[cH:2][n:3][c:4]2[n:5]1-[c:6]1[c:7]([cH:12][cH:13][cH:14][cH:15]1)[CH2:8][CH2:9][CH:10]2[NH:11][C:27]([C:24]1([NH:23][C:21]([O:20][C:16]([CH3:17])([CH3:18])[CH3:19])=[O:22])[CH2:25][CH2:26]1)=[O:28]

Participants

9

Reactant 8

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 8857Ethyl AcetateHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 757711-HydroxybenzotriazoleHCID 81531DiisopropylethylamineHCID 6883961-((tert-Butoxycarbonyl)amino)cyclopropanecarboxylic acidHCID 583040445,6-dihydro-4H-imidazo[1,2-a][1]benzazepin-4-amine

Product 1

HCID 67234386tert-butyl N-[1-(5,6-dihydro-4H-imidazo[1,2-a][1]benzazepin-4-ylcarbamoyl)cyclopropyl]carbamate

Sources & evidence

ORD record
ord-156f3bc5b1d74e17aabd2ec82e90c384
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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