Trifluoroacetic acid → 1-{4-[1-(Tert-butoxycarbonyl)-1,2,3,6-tetrahydropyridin-4-yl]phenyl}cyclopropane carboxylic acid

HRID 2155735Notes

Reaction equation

HRID 2155735 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][C:11]([OH:14])([c:15]2[cH:16][cH:17][c:18]([C:21]3([C:24](=[O:25])[OH:26])[CH2:22][CH2:23]3)[cH:19][cH:20]2)[CH2:12][CH2:13]1.[C:39]([O:40][C:41]([O:42][C:43]([O:44][C:45]([CH3:46])([CH3:47])[CH3:48])=[O:49])=[O:50])([CH3:51])([CH3:52])[CH3:53].[CH3:63][CH2:64][O:65][C:66]([CH3:67])=[O:68].[CH:54]([N:55]([CH2:56][CH3:57])[CH:58]([CH3:59])[CH3:60])([CH3:61])[CH3:62].[O:34]1[CH2:35][CH2:36][CH2:37][CH2:38]1.[OH:27][C:28]([C:29]([F:30])([F:31])[F:32])=[O:33]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH:10]=[C:11]([c:15]2[cH:16][cH:17][c:18]([C:21]3([C:24](=[O:25])[OH:26])[CH2:22][CH2:23]3)[cH:19][cH:20]2)[CH2:12][CH2:13]1

Participants

7

Reactant 6

HCID 6422Trifluoroacetic acidHCID 8028TetrahydrofuranHCID 8857Ethyl AcetateHCID 81531DiisopropylethylamineHCID 90495Di-tert-butyl dicarbonateHCID 666615921-(4-[1-(Tert-butoxycarbonyl)-4-hydroxypiperidin-4-yl]phenyl}cyclopropanecarboxylic acid

Product 1

HCID 666618331-{4-[1-(Tert-butoxycarbonyl)-1,2,3,6-tetrahydropyridin-4-yl]phenyl}cyclopropane carboxylic acid

Sources & evidence

ORD record
ord-e5bbe775e535479f97ec76a9952e8d39
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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