4-Methylmorpholine → HCID 66766929, compound

HRID 2195509Notes

Reaction equation

HRID 2195509 reaction equation
[F:1][C:2]1[CH:26]=[C:25]([N+:27]([O-:29])=[O:28])[CH:24]=[CH:23][C:3]=1[O:4][C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][C:13]=1[C:14](O)=[O:15])[N:10]([CH:17]1[CH2:22][CH2:21][CH2:20][CH2:19][O:18]1)[N:9]=[CH:8]2.[O:30]1[CH2:35][CH2:34][CH:33]([NH2:36])[CH2:32][CH2:31]1.CCN=C=NCCCN(C)C.C1C=CC2N(O)N=NC=2C=1.CN1CCOCC1>CN(C=O)C.CCOC(C)=O>[F:1][C:2]1[CH:26]=[C:25]([N+:27]([O-:29])=[O:28])[CH:24]=[CH:23][C:3]=1[O:4][C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][C:13]=1[C:14]([NH:36][CH:33]1[CH2:34][CH2:35][O:30][CH2:31][CH2:32]1)=[O:15])[N:10]([CH:17]1[CH2:22][CH2:21][CH2:20][CH2:19][O:18]1)[N:9]=[CH:8]2

Participants

8

Reactant 5

HCID 79724-MethylmorpholineHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 757711-HydroxybenzotriazoleHCID 4192234-AminotetrahydropyranHCID 66766833HCID 66766833, compound

Product 1

HCID 66766929HCID 66766929, compoundYield 81.2%

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 8857Ethyl AcetateSolvent

Procedure

The solution of 5-(2-fluoro-4-nitrophenoxy)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole-6-carboxylic acid (0.5 g, 1.25 mmol), tetrahydropyran-4-ylamine (0.13 g, 1.25 mmol), EDCI (0.24 g, 1.25 mmol), HOBT (0.17 g, 1.25 mmol), N-methylmorpholine (0.5 mL) in DMF (5 mL) is stirred at RT overnight. Then the reaction mixture is partitioned with saturated aqueous NH4Cl (20 mL) and EtOAc (50 mL). The organic phase is separated, dried over MgSO4, and concentrated. The residue is purified by silica gel column chromatography eluting with PE:EtOAc (1:1) to provide the product (0.49 g, 81.2% yield). MS (m/z): 485.1 (M+H).

Workup

  1. customThen the reaction mixture is partitioned with saturated aqueous NH4Cl (20 mL) and EtOAc (50 mL)
  2. customThe organic phase is separated
  3. dry with materialdried over MgSO4
  4. concentrationconcentrated
  5. customThe residue is purified by silica gel column chromatography
  6. washeluting with PE

Sources & evidence

ORD record
ord-9c7967e6d16f4cc7a8ddf0fd64c064dd
Source dataset
uspto-grants-2012_12
Patent number
USRE043878E1

Reaction notes

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