2-Chlorobenzaldehyde → HCID 11587130, compound

Temperature

-78 °C

Charge a flask with 1-cyclohexyl-5-methyl-pyrrolidin-2-one (U.S. Pat. No. 6,743,819, 500 mg, 2.8 mmol), dissolve in THF (30 mL) and cool to −78° C. under nitrogen. Add LDA (2M, 1.7 mL, 3.3 mmol) and stir at −78° C. for 10 minutes. Add 2-chlorobenzaldehyde (500 mg, 3.6 mmol) and warm to room temperature. Pour into saturated aqueous ammonium chloride and extract with methylene chloride. Dry over sodium sulfate, filter and concentrate. Dissolve the residue in THF (30 mL) and add triethylamine (360 mg, 3.6 mmol) and methanesulfonyl chloride (380 mg, 3.3 mmol). Stir at room temperature for 2 hours and filter. Add DBU (440 mg, 3.6 mmol) to the filtrate and stir overnight. Pour the reaction into water and extract with methylene chloride. Dry over sodium sulfate, filter and concentrate. Purify residue over silica gel (5:1 hexanes:ethyl acetate). Dissolve the residue in methanol (10 mL) and add 10% palladium on carbon (40 mg) and stir under a balloon of hydrogen for 3 days. Filter through celite® and concentrate. Purify over silica gel (9:1 hexanes:ethyl acetate) to afford two separable isomers.

1. extractionextract with methylene chloride
2. dry with materialDry over sodium sulfate
3. filtrationfilter
4. concentrationconcentrate
5. dissolutionDissolve the residue in THF (30 mL)
6. filtrationfilter
7. additionPour
8. extractionextract with methylene chloride
9. dry with materialDry over sodium sulfate
10. filtrationfilter
11. concentrationconcentrate
12. dissolutionDissolve the residue in methanol (10 mL)
13. additionadd 10% palladium on carbon (40 mg)
14. stirringstir under a balloon of hydrogen for 3 days
15. filtrationFilter through celite®
16. concentrationconcentrate
17. customPurify over silica gel (9:1 hexanes:ethyl acetate)
18. customto afford two separable isomers

ORD record

ord-ca4c7873b97a4339a3165b64e97609da

Source dataset

uspto-grants-2010_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07713979B2