Benzene → 1-Butylcyclobutanecarboxylic Acid

HRID 2310155Notes

Reaction equation

HRID 2310155 reaction equation
[CH2:16]([CH2:17][CH2:18][CH3:19])[I:20].[CH2:40]1[O:41][CH2:42][CH2:43][CH2:44]1.[CH3:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH3:39].[CH:1]([N-:2][CH:3]([CH3:4])[CH3:5])([CH3:6])[CH3:7].[CH:9]1([C:13](=[O:14])[OH:15])[CH2:10][CH2:11][CH2:12]1.[ClH:21].[Li+:8].[O:28]1[CH2:29][CH2:30][CH2:31][CH2:32]1.[cH:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1>>[C:9]1([C:13](=[O:14])[OH:15])([CH2:16][CH2:17][CH2:18][CH3:19])[CH2:10][CH2:11][CH2:12]1

Participants

9

Reactant 8

HCID 241BenzeneHCID 313Hydrochloric AcidHCID 8028Tetrahydrofuran2×HCID 8900HeptaneHCID 10962Butyl iodideHCID 19494Cyclobutanecarboxylic acidHCID 28486Lithium ionHCID 5062348Diisopropylamide

Product 1

HCID 133895511-Butylcyclobutanecarboxylic Acid

Sources & evidence

ORD record
ord-ac3fd4fc2e844fa88f61e95dd28f876b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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