Hydrochloric Acid → 6-[2-[2-(cyclobutylmethoxy)-3-(difluoromethoxy)phenyl]ethenyl]-N-(4-cyclopropyl-1,3-thiazol-2-yl)imidazo[2,1-b][1,3]thiazole-5-carboxamide

HRID 2318466Notes

Reaction equation

HRID 2318466 reaction equation
[CH2:60]1[O:61][CH2:62][CH2:63][CH2:64]1.[CH3:39][CH2:40][N:41]=[C:42]=[N:43][CH2:44][CH2:45][CH2:46][N:47]([CH3:48])[CH3:49].[CH3:51][N:52]([c:53]1[cH:54][cH:55][n:56][cH:57][cH:58]1)[CH3:59].[CH:1]1([CH2:5][O:6][c:7]2[c:8]([CH:17]=[CH:18][c:19]3[n:20][c:21]4[s:22][cH:23][cH:24][n:25]4[c:26]3[C:27](=[O:28])[OH:29])[cH:9][cH:10][cH:11][c:12]2[O:13][CH:14]([F:15])[F:16])[CH2:2][CH2:3][CH2:4]1.[CH:30]1([c:33]2[n:34][c:35]([NH2:38])[s:36][cH:37]2)[CH2:31][CH2:32]1.[ClH:50].[O:65]=[CH:66][N:67]([CH3:68])[CH3:69]>>[CH:1]1([CH2:5][O:6][c:7]2[c:8]([CH:17]=[CH:18][c:19]3[n:20][c:21]4[s:22][cH:23][cH:24][n:25]4[c:26]3[C:27](=[O:28])[NH:38][c:35]3[n:34][c:33]([CH:30]4[CH2:31][CH2:32]4)[cH:37][s:36]3)[cH:9][cH:10][cH:11][c:12]2[O:13][CH:14]([F:15])[F:16])[CH2:2][CH2:3][CH2:4]1

Participants

8

Reactant 7

HCID 313Hydrochloric AcidHCID 6228DimethylformamideHCID 8028TetrahydrofuranHCID 142844-(Dimethylamino)pyridineHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 6744564-Cyclopropyl-1,3-thiazol-2-amineHCID 675494606-[2-[2-(Cyclobutylmethoxy)-3-(difluoromethoxy)phenyl]ethenyl]imidazo[2,1-b][1,3]thiazole-5-carboxylic acid

Product 1

HCID 752158596-[2-[2-(cyclobutylmethoxy)-3-(difluoromethoxy)phenyl]ethenyl]-N-(4-cyclopropyl-1,3-thiazol-2-yl)imidazo[2,1-b][1,3]thiazole-5-carboxamide

Sources & evidence

ORD record
ord-0092e9e127ba45f597837f1e2f54502c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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