Hydrochloric Acid → 4-Chloropyridine-3-carbaldehyde

HRID 2324877Notes

Reaction equation

HRID 2324877 reaction equation
[CH2:34]([Cl:35])[Cl:36].[CH2:37]1[O:38][CH2:39][CH2:40][CH2:41]1.[CH3:17][CH:18]([N-:19][CH:20]([CH3:21])[CH3:22])[CH3:23].[CH:24](=[O:25])[O:26][CH2:27][CH3:28].[Cl:1][c:2]1[cH:3][cH:4][n:5][cH:6][cH:7]1.[Cl:9][c:10]1[cH:11][cH:12][n:13][cH:14][cH:15]1.[ClH:8].[Li+:16].[Na+:33].[O-:29][C:30]([OH:31])=[O:32].[OH2:42]>>[Cl:1][c:2]1[c:3]([CH:24]=[O:25])[cH:4][n:5][cH:6][cH:7]1

Participants

11

Reactant 10

HCID 313Hydrochloric AcidHCID 769Bicarbonate IonHCID 923Sodium ionHCID 962WaterHCID 6344DichloromethaneHCID 8025Ethyl formateHCID 8028TetrahydrofuranHCID 122884-Chloropyridine2×HCID 28486Lithium ionHCID 5062348Diisopropylamide

Product 1

HCID 140466744-Chloropyridine-3-carbaldehyde

Sources & evidence

ORD record
ord-b2ff4a9e9f924d7f8881d2cec4a9c3c0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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