Hydrochloric Acid → 2-Cyano-4'-methylbiphenyl

HRID 2327205Notes

Reaction equation

HRID 2327205 reaction equation
[Br:14][c:15]1[c:16]([C:17]#[N:18])[cH:19][cH:20][cH:21][cH:22]1.[Br:1][c:2]1[cH:3][cH:4][c:5]([CH3:8])[cH:6][cH:7]1.[C:9]([Li:10])([CH3:11])([CH3:12])[CH3:13].[CH2:24]1[O:25][CH2:26][CH2:27][CH2:28]1.[ClH:23].[Ni:29]([Cl:30])[Cl:31].[OH2:70].[c:32]1([P:33]([c:34]2[cH:35][cH:36][cH:37][cH:38][cH:39]2)[c:40]2[cH:41][cH:42][cH:43][cH:44][cH:45]2)[cH:46][cH:47][cH:48][cH:49][cH:50]1.[c:51]1([P:52]([c:53]2[cH:54][cH:55][cH:56][cH:57][cH:58]2)[c:59]2[cH:60][cH:61][cH:62][cH:63][cH:64]2)[cH:65][cH:66][cH:67][cH:68][cH:69]1>>[c:2]1(-[c:15]2[c:16]([C:17]#[N:18])[cH:19][cH:20][cH:21][cH:22]2)[cH:3][cH:4][c:5]([CH3:8])[cH:6][cH:7]1

Participants

9

Reactant 8

HCID 313Hydrochloric AcidHCID 962WaterHCID 78054-BromotolueneHCID 8028TetrahydrofuranHCID 11776Triphenylphosphine2×HCID 162722-BromobenzonitrileHCID 24385Nickel DichlorideHCID 178418306HCID 178418306, compound

Product 1

HCID 1455122-Cyano-4'-methylbiphenyl

Sources & evidence

ORD record
ord-d45d9b96408041d9a63c0a362d58ad71
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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