Tetrahydrofuran → [4-(1-Methoxycyclopropyl)phenylethynyl]-trimethylsilane

HRID 2347001Notes

Reaction equation

HRID 2347001 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]([C:8]2([O:11][CH3:12])[CH2:9][CH2:10]2)[cH:6][cH:7]1.[CH3:13][Si:14]([CH3:15])([CH3:16])[C:17]#[CH:18].[CH3:19][CH2:20][N:21]([CH2:22][CH3:23])[CH2:24][CH3:25].[Cu:31][I:32].[O:26]1[CH2:27][CH2:28][CH2:29][CH2:30]1.[Pd:33]([Cl:34])[Cl:35].[c:36]1([P:37]([c:38]2[cH:39][cH:40][cH:41][cH:42][cH:43]2)[c:44]2[cH:45][cH:46][cH:47][cH:48][cH:49]2)[cH:50][cH:51][cH:52][cH:53][cH:54]1.[c:55]1([P:56]([c:57]2[cH:58][cH:59][cH:60][cH:61][cH:62]2)[c:63]2[cH:64][cH:65][cH:66][cH:67][cH:68]2)[cH:69][cH:70][cH:71][cH:72][cH:73]1>>[c:2]1([C:18]#[C:17][Si:14]([CH3:13])([CH3:15])[CH3:16])[cH:3][cH:4][c:5]([C:8]2([O:11][CH3:12])[CH2:9][CH2:10]2)[cH:6][cH:7]1

Participants

8

Reactant 7

HCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 11776Triphenylphosphine2×HCID 24290Palladium ChlorideHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 66111TrimethylsilylacetyleneHCID 22568990HCID 22568990, compound

Product 1

HCID 22568890[4-(1-Methoxycyclopropyl)phenylethynyl]-trimethylsilane

Sources & evidence

ORD record
ord-973a23b07bde46cd8c04d22857090321
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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