Tetrahydrofuran → N-[5-[(2-Chloro-4-pyrimidinyl)ethynyl]-2-(methyloxy)phenyl]-2,2,2-trifluoroacetamide

HRID 315832Notes

Reaction equation

HRID 315832 reaction equation
[C:9](#[CH:10])[c:11]1[cH:12][cH:13][c:14]([O:24][CH3:25])[c:15]([NH:17][C:18]([C:19]([F:20])([F:21])[F:22])=[O:23])[cH:16]1.[CH2:26]1[O:27][CH2:28][CH2:29][CH2:30]1.[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6]([Cl:8])[n:7]1.[Cu:72][I:73].[Pd:31]([Cl:32])[Cl:33].[c:34]1([P:35]([c:36]2[cH:37][cH:38][cH:39][cH:40][cH:41]2)[c:42]2[cH:43][cH:44][cH:45][cH:46][cH:47]2)[cH:48][cH:49][cH:50][cH:51][cH:52]1.[c:53]1([P:54]([c:55]2[cH:56][cH:57][cH:58][cH:59][cH:60]2)[c:61]2[cH:62][cH:63][cH:64][cH:65][cH:66]2)[cH:67][cH:68][cH:69][cH:70][cH:71]1>>[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6]([C:10]#[C:9][c:11]2[cH:12][cH:13][c:14]([O:24][CH3:25])[c:15]([NH:17][C:18]([C:19]([F:20])([F:21])[F:22])=[O:23])[cH:16]2)[n:7]1

Participants

7

Reactant 6

HCID 8028TetrahydrofuranHCID 11776Triphenylphosphine2×HCID 24290Palladium ChlorideHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 775312,4-DichloropyrimidineHCID 59511434N-[5-ethynyl-2-(methyloxy)phenyl]-2,2,2-trifluoroacetamide

Product 1

HCID 59511410N-[5-[(2-Chloro-4-pyrimidinyl)ethynyl]-2-(methyloxy)phenyl]-2,2,2-trifluoroacetamide

Sources & evidence

ORD record
ord-9698121597d8431380ea312417e3d0ad
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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