Triphenylphosphine → 6-Vinyl-8-(3-nitrophenyl)-1,7-naphthyridine

HRID 369030Notes

Reaction equation

HRID 369030 reaction equation
FC(F)(F)S(O[C:7]1[CH:8]=[C:9]2[C:14](=[C:15]([C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([N+:23]([O-:25])=[O:24])[CH:18]=3)[N:16]=1)[N:13]=[CH:12][CH:11]=[CH:10]2)(=O)=O.[CH:28]([Sn](CCCC)(CCCC)CCCC)=[CH2:29].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[Cl-].[Li+]>O1CCCC1.C(OCC)(=O)C.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd]>[CH:28]([C:7]1[CH:8]=[C:9]2[C:14](=[C:15]([C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([N+:23]([O-:25])=[O:24])[CH:18]=3)[N:16]=1)[N:13]=[CH:12][CH:11]=[CH:10]2)=[CH2:29]

Participants

8

Reactant 4

HCID 11776TriphenylphosphineHCID 81998TributylvinyltinHCID 433294Lithium ChlorideHCID 108109346-Trifluoromethylsulfonyloxy-8-(3-nitrophenyl)-1,7-naphthyridine

Product 1

HCID 232846366-Vinyl-8-(3-nitrophenyl)-1,7-naphthyridine

Reagents, catalysts & solvents 3

HCID 6505921(1E,4E)-1,5-diphenylpenta-1,4-dien-3-one; palladiumCatalystHCID 8028TetrahydrofuranSolventHCID 8857Ethyl AcetateSolvent

Procedure

To a solution of 6-trifluoromethylsulfonyloxy-8-(3-nitrophenyl)-1,7-naphthyridine (250 mg, 0.62 mmol prepared according to example 13) in tetrahydrofuran (3 ml) is added vinyltributylstannane (218 mg, 0.68 mmol), bis(dibenzylideneacetone)palladium (14 mg, 0.025 mmol), triphenylphosphine (13 mg, 0.049 mmol) and lithium chloride (78 mg, 1.86 mmol). The mixture is kept at 70° C. overnight. The solution is diluted with ethyl acetate, filtered and washed with water. Preparative thin layer chromatography (8:2 dichloromethane/n-hexane) affords the title compound. Mass M+H 278; mp 145-151° C.

Workup

  1. filtrationfiltered
  2. washwashed with water

Sources & evidence

ORD record
ord-26bd93baa1d74ba2ada9eb9a7333e5c1
Source dataset
uspto-grants-2000_10
Patent number
US06136821

Reaction notes

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