N-Methylbenzylamine → HCID 18944400, compound

HRID 400211Notes

Reaction equation

HRID 400211 reaction equation
[C:1]([OH:8])(=O)[CH2:2][CH2:3][C:4]([CH3:6])=[O:5].C(N(CC)CC)C.ClC(OCC(C)C)=O.[CH3:24][NH:25][CH2:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1>CC(C)=O>[CH2:26]([N:25]([CH3:24])[C:1](=[O:8])[CH2:2][CH2:3][C:4](=[O:5])[CH3:6])[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1

Participants

6

Reactant 4

HCID 7669N-MethylbenzylamineHCID 8471TriethylamineHCID 11579Levulinic AcidHCID 62365Isobutyl chloroformate

Product 1

HCID 18944400HCID 18944400, compoundYield 88.6%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A! Starting from 10 g (0.086 mole) of levulinic acid, 11.8 ml (0.086 mole) of triethylamine, 11.2 ml (0.086 mole) of isobutyl chloroformate and 13.3 ml (0.103 mole) of N-methyl-benzylamine in 200 ml of acetone, and following the procedure of Example 6,B!, there were obtained 16.7 g (yield: 88%) of N-benzyl-N-methyl-4-oxo-pentanamide.

Sources & evidence

ORD record
ord-bbc053c6d9cc4676aa4324fea3fc855d
Source dataset
uspto-grants-1998_10
Patent number
US05827881

Reaction notes

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