Formic Acid → HCID 59364492, compound

HRID 404260Notes

Reaction equation

HRID 404260 reaction equation
FC(F)(F)S(O[C:7]1[CH2:12][CH:11]=[C:10]([CH2:13]OC2CCCCO2)[O:9][CH:8]=1)(=O)=O.[C:23]1([CH3:44])C=CC=CC=1P(C1C=CC=CC=1C)C1C=CC=CC=1C.C(N(CC)CC)C.[CH:52]([OH:54])=[O:53].CN(C=[O:59])C>C([O-])(=O)C.[Pd+2].C([O-])(=O)C>[CH2:13]([C:10]1[O:9][C:8]([C:52]([OH:54])=[O:53])=[CH:7][C:12](=[O:59])[CH:11]=1)[CH2:23][CH3:44]

Participants

7

Reactant 5

HCID 284Formic AcidHCID 6228DimethylformamideHCID 8471TriethylamineHCID 80271Tri-o-tolylphosphineHCID 131731596HCID 131731596, compound

Product 1

HCID 59364492HCID 59364492, compound

Reagents, catalysts & solvents 1

HCID 167845palladium(II) acetateCatalyst

Conditions

Temperature
60 °C

Procedure

7.00 g of 4-oxo-24(E)-propenyl)-6-(tetrahydropyran-2-yloxymethyl)-4H-pyran-3-yl trifluoromethanesulfonate were dissolved in 40.8 ml of DMF, and 75.8 mg of palladium(II) acetate, 154 mg of tri-(o-tolyl)-phosphine, 7.07 ml of triethylamine and 0.64 ml of formic acid were added. The reaction mixture was heated at 60° C. for 1 h.

Sources & evidence

ORD record
ord-a400190eb793462abc9ef9f2f89730cb
Source dataset
uspto-grants-2014_06
Patent number
US08748483B2

Reaction notes

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