反应详情

IPEA (1.05 mL) and 1-ethyl-3-(dimethylaminopropyl)carbodiimide hydrochloride (1.16 g) were sequentially added to a solution of 3-methoxy-4-(4-methylimidazol-1-yl)benzoic acid (CAS#937026-26-1, 933 mg), benzyl carbazate (737 mg) and HOBT (817 mg) in DMF (15 mL), and the mixture was stirred at room temperature overnight. Ethyl acetate, ice water and a saturated sodium bicarbonate solution were added to the reaction solution, and the organic layer was separated. The resulting organic layer was sequentially washed with water and brine. The combined aqueous layer was extracted with ethyl acetate. The combined organic layer was dried over anhydrous magnesium sulfate and then concentrated under reduced pressure. Ethyl acetate and NH silica gel were added to the resulting residue and then the mixture was concentrated under reduced pressure.

1. customthe organic layer was separated
2. washThe resulting organic layer was sequentially washed with water and brine
3. extractionThe combined aqueous layer was extracted with ethyl acetate
4. dry with materialThe combined organic layer was dried over anhydrous magnesium sulfate
5. concentrationconcentrated under reduced pressure
6. additionEthyl acetate and NH silica gel were added to the resulting residue
7. concentrationthe mixture was concentrated under reduced pressure