反应详情

Into a solution of 0.75 g of propanol and 1.90 mL of triethylamine in 10 mL of tetrahydrofuran, a solution of 2.50 g of 4-nitrophenyl chloroformate in 15 mL of tetrahydrofuran was dropped under cooling on ice. After stirring at room temperature for 20 min, ethyl acetate and water were added to the reaction mixture. The organic layer was separated, washed with water and a saturated sodium chloride aqueous solution successively, dried over anhydrous magnesium sulfate, followed by solvent removal by evaporation under reduced pressure. To the residue, hexane was added, and insoluble matters were removed by filtration. After removing the solvent by evaporation under reduced pressure, 2.59 g of 4-nitrophenyl propyl carbonate was obtained as a light yellow oily matter.

1. temperatureunder cooling on ice
2. customThe organic layer was separated
3. washwashed with water
4. dry with materiala saturated sodium chloride aqueous solution successively, dried over anhydrous magnesium sulfate
5. customfollowed by solvent removal by evaporation under reduced pressure
6. additionTo the residue, hexane was added
7. custominsoluble matters were removed by filtration
8. customAfter removing the solvent
9. customby evaporation under reduced pressure