反应详情

Rink resin (306 mg; loading 0.43 mmol/g) functionalized with Arg(Boc)2 was coupled with 146 mg of 5-hydroxy-2-nitrobenzoic acid in the presence of DIC (136 mg) and HOBt (140 mg) in DMF (2 ml) for 3 h at room temperature. The resin was then washed and treated with a 15% solution of benzyltrimethylammonium hydroxide in DMF for 60 min. The resin was washed with DMF, 10% acetic acid in DMF, DMF and DCM and dried in vacuo for 4 h. The dried resin was washed with anhydrous THF and mixed with 534 mg (2 mmol) of triphenylphosphane, 422 mg (2 mmol) of 2-(2,4-dichlorophenyl)ethanol and 400 μl (2 mmol) of DIAD in dry THF. The mixture was kept overnight at room temperature. The resin was washed and treated with 415 mg of tin dichloride monohydrate in 2 ml of DMF and 0.5 ml of trifluoroethanol. The reduction was continued overnight at room temperature. The resin was washed and dried, and the final product was cleaved off and processed as described in Example 1.

1. washThe resin was then washed
2. additiontreated with a 15% solution of benzyltrimethylammonium hydroxide in DMF for 60 min
3. washThe resin was washed with DMF, 10% acetic acid in DMF, DMF and DCM
4. customdried in vacuo for 4 h
5. washThe dried resin was washed with anhydrous THF
6. washThe resin was washed
7. additiontreated with 415 mg of tin dichloride monohydrate in 2 ml of DMF and 0.5 ml of trifluoroethanol
8. waitThe reduction was continued overnight at room temperature
9. washThe resin was washed
10. customdried