Ammonia → Methylamide

HRID 442274Notes

Reaction equation

HRID 442274 reaction equation
CN.[CH2:3]([NH:5]CC)C.[CH3:8][N:9]([CH3:13])[CH2:10][CH2:11][NH2:12].NN.[NH2:16][OH:17].N1CCOCC1.C(N1CCCCC1)C.OCCN1CCCCC1.OCCN.N>>[CH3:3][NH-:5].[CH3:8][N:9]([CH3:13])[CH2:10][CH2:11][NH-:12].[OH:17][NH-:16]

Participants

13

Reactant 10

HCID 222AmmoniaHCID 700EthanolamineHCID 787HydroxylamineHCID 6329MethylamineHCID 8021DiethylamineHCID 8083MorpholineHCID 9321HydrazineHCID 13007N-EthylpiperidineHCID 18232N-PiperidinoethanolHCID 66053N,N-Dimethylethylenediamine

Product 3

HCID 21952893MethylamideHCID 86621573HCID 86621573, compoundHCID 178514248HCID 178514248, compound

Procedure

Similarly, when methylamine, diethylamine, β-dimethylaminoethylamine, hydrazine, hydroxylamine, morpholine, N-ethylpiperidine, N-(β-hydroxyethyl)-piperidine, or β-hydroxyethylamine are used in place of ammonia in the above example, there are obtained the corresponding N-methylamide, N-diethylamide, N-(β-dimethylaminoethyl)-amide, hydrazide, N-hydroxyamide, morpholide, 4-ethylpiperidide, 4-(β-hydroxyethyl)-piperidide, or β-hydroxylethylamide, respectively.

Sources & evidence

ORD record
ord-4a53e4f220194357a5fcc69bf0767a02
Source dataset
uspto-grants-1977_08
Patent number
US04044049

Reaction notes

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