Phenylacetic Acid → HCID 69735012, compound

HRID 496793Notes

Reaction equation

HRID 496793 reaction equation
[C:1]1([CH2:7][C:8]([OH:10])=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:11][S:12]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[C:21]1[CH:26]=[CH:25][C:24]([NH2:27])=[CH:23][CH:22]=1)(=[O:14])=[O:13].Cl.CN(C)CCC[N:34]=[C:35]=[N:36][CH2:37][CH3:38].ON1[C:45]2[CH:46]=CC=[CH:49][C:44]=2N=N1.CN1[CH2:56][CH2:55][O:54]CC1.CN(C=[O:61])C>O>[CH3:11][S:12]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[C:21]1[CH:22]=[CH:23][C:24]([NH:27][C:8](=[O:10])[CH:7]([O:54][C:55]2[CH:56]=[CH:46][CH:45]=[C:44]([C:35]3[N:36]=[C:37]([CH3:38])[O:61][N:34]=3)[CH:49]=2)[C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)=[CH:25][CH:26]=1)(=[O:13])=[O:14]

Participants

8

Reactant 6

HCID 999Phenylacetic AcidHCID 6228DimethylformamideHCID 79724-MethylmorpholineHCID 757711-HydroxybenzotriazoleHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 108005164-(2-Methylsulfonylphenyl)aniline

Product 1

HCID 69735012HCID 69735012, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 102 mg (0.330 mmol) of [3-(5-methyl[1,2,4)]oxadiazol-3-yl)phenoxy]-2-phenylacetic acid, 81.6 mg (0.330 mmol) of 2′-methanesulfonylbiphenyl-4-ylamine, 63.3 mg (0.330 mol) of N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (DAPECI) and 44.6 mg (0.330 mmol) of 1-hydroxybenzotriazole (HOBt) in 5 ml of DMF is treated with 0.036 ml (0.33 mmol) of 4-methylmorpholine and stirred at room temperature for 18 hours. The reaction mixture is added to water and the precipitate is filtered off. A colourless solid is obtained; FAB 540

Workup

  1. filtrationthe precipitate is filtered off
  2. customA colourless solid is obtained

Sources & evidence

ORD record
ord-b7a4450eb6c14346967b8bcd53fbee3b
Source dataset
uspto-grants-2005_09
Patent number
US06946489B2

Reaction notes

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